Mp39-11 Toward Personalized Medicine for an Interstitial Cystitis Individualized Diagnosis Using a New Bladder Inflammation Score
Year: 2018
Type: article
Abstract: shift artifacts in the measurements of bladder wall thickness (BWT), CNR and T1 from 20 pixels.RESULTS: Subjects did not complain of any pain or discomfort from 50mL NCM instillation, beyond that caused by the catheterization process.Four-fold increase in bladder wall CNR (*p<0.02)and spatial resolution of 0.35mm with minimal influence of artifacts made it feasible to determine the significant bladder wall thinning of ~0.46mm (*p<0.05)from 50mL NCM.Pre-contrast bladder wall T1 of 1544Æ 34.2ms was shortened by Gadobutrol diffusion into the bladder wall to 860.09 Æ13.95 ms in Hunner type IC (*p<0.0001,two way ANOVA) relative to only 1257.42Æ 20.59 ms and 1258.16Æ 6.16ms in non-Hunner type IC and controls, respectively.Post-contrast pixel-wise T1 mapping differentiated the bladder wall into layers with greater Gadobutrol mediated T1 shortening in pixels representing the urothelium and lamina propria (blue and green) compared to the detrusor region (yellow in attached picture).CONCLUSIONS: Recapitulation of the published pre-clinical findings in the clinical setting demonstrates the safety and feasibility of NCM enhanced MRI to achieve artifact-free differential contrast and spatial resolution of human bladder wall, which is suitable for first pixelwise measurement of T1 in both pre-and post-contrast settings.Quantitative T1 measurement holds promise in the non-invasive characterization of diffuse pathophysiological changes in bladder wall of IC patients.
Source: The Journal of Urology
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2796235179