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Mp18-07 Using Microrna to Predict Bladder Recurrence After Nephroureterectomy for Upper Tract Urothelial Carcinoma

Year: 2018

Type: article

Abstract: median of 66 years vs 71 years, p¼0.0001) and had their NU in the more recent years (median surgery year of 2013 vs 2007, p<0.0001) than patients who did not undergo cisplatin-based NAC.Response rates on imaging were: 16% complete response; 52% partial response; 27% stable disease; 5% progression.Thirty-six patients (58%; 95% CI 45%, 70%) responded to cisplatin-based chemotherapy on pathology.Radiological response was significantly associated with lower tumor stage on pathology (74% among complete or partial response vs 25% among stable disease or progression, p¼0.0004.On multivariable analysis, radiological response was associated with better overall survival (HR 0.48) although confidence intervals were wide (95% CI 0.17, 1.31; p¼0.2) due to low event rates (16 deaths).CONCLUSIONS: Radiological response rates following NAC in UTUC is significantly associated with pathologic response and nonsignificantly associated with better overall survival following NU.It can be a useful preoperative tool to counsel and optimize management of UTUC patients.

Source: The Journal of Urology

DOI: 10.1016/j.juro.2018.02.583

Authors: Alison Levy, Travis Sullivan, Brendan Browne, Kristian Stensland, Eric Burks, Chintan Patel, Joshua Warrick, Jay Raman, David Canes, Kimberly Rieger-Christ

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2796256304

FWCI:

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