Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts
Year: 2018
Type: article
Abstract: Numerous attempts to produce antiviral vaccines by harnessing memory CD8 T cells have failed. A barrier to progress is that we do not know what makes an Ag a viable target of protective CD8 T cell memory. We found that in mice susceptible to lethal mousepox (the mouse homolog of human smallpox), a dendritic cell vaccine that induced memory CD8 T cells fully protected mice when the infecting virus produced Ag in large quantities and with rapid kinetics. Protection did not occur when the Ag was produced in low amounts, even with rapid kinetics, and protection was only partial when the Ag was produced in large quantities but with slow kinetics. Hence, the amount and timing of Ag expression appear to be key determinants of memory CD8 T cell antiviral protective immunity. These findings may have important implications for vaccine design.
Source: The Journal of Immunology
Institutions: Fox Chase Cancer Center, Thomas Jefferson University
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Immune Mechanisms That Control Ectromelia Virus Infection, G400088502, Mechanisms of NK Cell Migration to the Draining Lymph Node in Viral Infections, Training Program in Cancer Research, Inflammatory monocytes in the draining lymph node of ECTV infected mice, Translational Research in Cancer
OpenAlex ID: W2796792946