Work

MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress

Year: 2018

Type: article

Abstract: The mitoCPR unclogs mitochondria The import of proteins into mitochondria is essential for cell viability. How cells respond when mitochondrial protein import is impaired is poorly understood. Weidberg and Amon showed that upon mitochondrial import stress, yeast cells mounted a response known as the mitoCPR. mitoCPR was activated when mitochondrial protein import was impaired and unimported precursors accumulated on the organelle's surface. mitoCPR restored mitochondrial functions by clearing stalled proteins from the import channels. It did this by inducing expression of Cis1, which recruited the adenosine triphosphatase Msp1 to import channels to remove unimported precursors and target them for degradation by the proteasome. Science , this issue p. eaan4146

Source: Science

DOI: 10.1126/science.aan4146

Authors: Hilla Weidberg, Angelika Amon

Institutions: Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green