Year: 2018
Type: article
Abstract: The immune system evolved to efficiently eradicate invading bacteria and terminate inflammation through balancing inflammatory and regulatory T-cell responses. In autoimmune arthritis, pathogenic TH17 cells induce bone destruction and autoimmune inflammation. However, whether a beneficial function of T-cell-induced bone damage exists is unclear. Here, we show that bone-damaging T cells have a critical function in the eradication of bacteria in a mouse model of periodontitis, which is the most common infectious disease. Bacterial invasion leads to the generation of specialized TH17 cells that protect against bacteria by evoking mucosal immune responses as well as inducing bone damage, the latter of which also inhibits infection by removing the tooth. Thus, bone-damaging T cells, which may have developed to stop local infection by inducing tooth loss, function as a double-edged sword by protecting against pathogens while also inducing skeletal tissue degradation.
Source: Nature Communications
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $6,990
Funders: Uehara Memorial Foundation, National Center for Global Health and Medicine, Kowa Company, Kowa Life Science Foundation, University of Tokyo, Kanae Foundation for the Promotion of Medical Science, University of California, San Francisco, Chugai Pharmaceutical, Japan Society for the Promotion of Science
Awards: Pathological significance of T cell plasticity in arthritis and development of novel therapies, Elucidation of the border region between tumor and bone marrow cells in bone metastasis, Analysis of regulation of the biological systems by novel calcium signal transducers, Mechanisms underlying the deficiency of oral immunity and its effect on systemic organ network, Biological crosstalk of between mastication and brain function, Promotion of osteoimmunology for understanding the new regulatory systems of vertebrate, Molecular basis for T cell repertoire formation in thymic microenvironment, G7475120045, 新規免疫細胞サブセットを標的とした炎症性骨破壊制御法の確立
OpenAlex ID: W2796965506