Interferon- Gamma- Inducible Guanosine Triphosphate Cyclohydrolase 1 (GTP-CH1) Pathway Is Associated with Frailty in Egyptian Elderly.
Year: 2018
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Chronic low-grade inflammation may be a cardinal pathophysiologic feature in the pathogenesis of frailty. Interferon-gamma (INF-γ) is an understudied proinflammatory cytokine in frailty that induces many inflammatory pathways including the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) pathway. Our aim was to evaluate the GTP-CH1 pathway in Egyptian frail elderly subjects. METHODS: INF-γ, neopterin, and nitric oxide (NO) levels were measured in 80 participants. RESULTS: Both pre-frail and frail subjects had significantly higher levels of INF-γ, neopterin and lower levels of NO than the control group. These biomarkers were associated with the risk of frailty with significant odds ratio. CONCLUSION: Elevated INF-γ levels in frail subjects may activate the GTP-CH1 pathway. Elevated neopterin and reduced NO levels correlated with an active GTP-CH1 pathway. The risk of frailty increased with elevated INF-γ and neopterin and decreased with elevated NO levels.
Source: Europe PMC (PubMed Central)
Institution: Ain Shams University
Language: English
Topic: Frailty in Older Adults
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2797344403