Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains
Year: 2018
Type: article
Abstract: Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death worldwide today. Escalating application of genomic techniques has expedited the identification of increasing number of mutations associated with drug resistance in Mycobacterium tuberculosis. Unfortunately the prevalence of bacillary resistance becomes alarming in many parts of the world, with the daunting scenarios of multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and total drug-resistant tuberculosis (TDR-TB), due to number of resistance pathways, alongside some apparently obscure ones. Recent advances in the understanding of the molecular/ genetic basis of drug targets and drug resistance mechanisms have been steadily made. Intriguing findings through whole genome sequencing and other molecular approaches facilitate the further understanding of biology and pathology of M. tuberculosis for the development of new therapeutics to meet the immense challenge of global health.
Institutions: Chinese Academy of Sciences, Guangzhou Institutes of Biomedicine and Health, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, State Key Laboratory of Respiratory Disease, University of Chinese Academy of Sciences, Anhui University, Guangzhou Chest Hospital, Institut Pasteur Korea, Chinese University of Hong Kong
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funders: Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Research Foundation, National Natural Science Foundation of China, Chinese Academy of Sciences, Ministry of Science, ICT and Future Planning, University of Chinese Academy of Sciences, Russian Academy of Sciences
OpenAlex ID: W2797704881