Work

Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use

Year: 2018

Type: article

Abstract: In addition to electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), vagus nerve stimulation (VNS) is one of the approved neurostimulation tools for treatment of major depression. VNS is particularly used in therapy-resistant depression (TRD) and exhibits antidepressive and augmentative effects. In long-term treatment, up to two-thirds of patients respond. This mini-review provides a comprehensive overview of augmentation pharmacotherapy and neurostimulation-based treatment strategies, with a special focus on VNS in TRD, and provides practical clinical advice for how to select TRD patients for add-on neurostimulation treatment strategies.

Source: Frontiers in Neuroscience

DOI: 10.3389/fnins.2018.00239

Authors: Helge H. O. Müller, Sebastian Moeller, Caroline Lücke, Alexandra P. Lam, Niclas Braun, Alexandra Philipsen

Institutions: University Hospital Bonn, Carl von Ossietzky Universität Oldenburg

Language: English

Topic: Vagus Nerve Stimulation Research

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801