Work

Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome

Year: 2018

Type: article

Abstract: Exposure to high doses of ionizing radiation can cause lethal injury to normal tissue, thus inducing acute radiation syndrome. Acute radiation syndrome is caused by depletion of bone marrow cells (hematopoietic syndrome) and irreparable damage to the epithelial cells in the gastrointestinal tract (gastrointestinal syndrome). Although radiation initiates apoptosis in the hematopoietic and gastrointestinal compartments within the first few hours after exposure, alternative mechanisms of cell death may contribute to injury in these radiosensitive tissues. In this study, we utilized mice lacking a critical regulator of necroptosis, receptor interacting protein 3 (RIP3) kinase, to characterize the role of RIP3 in normal tissue toxicity after irradiation. Our results suggest that RIP3-mediated signaling is not a critical driver of acute radiation syndrome.

Source: Radiation Research

DOI: 10.1667/rr15001.1

Authors: Katherine D. Castle, Andrea R. Daniel, Everett J. Moding, Lixia Luo, Chang-Lung Lee, David G. Kirsch

Institution: Duke Medical Center

Language: English

Topic: Effects of Radiation Exposure

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Food and Drug Administration, National Cancer Institute, National Institute of Allergy and Infectious Diseases