Work

Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor

Year: 2018

Type: article

Abstract: Key Points GTPase RAB1B is a direct transcriptional target of RUNX1 in MK/platelets and is downregulated in RUNX1 haplodeficiency. RUNX1 downregulation is associated with defective RAB1B-related ER-to-Golgi transport and alterations in α-granule vWF.

Source: Blood Advances

DOI: 10.1182/bloodadvances.2017014274

Authors: Gauthami Jalagadugula, Lawrence E. Goldfinger, Guangfen Mao, Michele P. Lambert, A. Koneti Rao

Institutions: Temple University, Children's Hospital of Philadelphia, University of Pennsylvania

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,800