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Traumatic Lumbar Puncture is Unlikely to Reduce Modern Molecular Detection of HSV Encephalitis (HSVE)

Year: 2018

Type: article

Abstract: Polymerase chain reaction (PCR) is the gold-standard for diagnosing HSVE, but may be inhibited by blood contamination.We mimicked traumatic lumbar puncture and measured its effect on the molecular detection of HSV-1 in CSF.Clinically meaningful reductions in sensitivity were not observed.Pre-PCR processing allows sensitive detection of HSVE despite traumatic lumbar puncture.

Source: Clinical Microbiology Open Access

DOI: 10.4172/2327-5073.1000310

Authors: Kacy A Ramirez, Rebecca Thompson, Ishita Pareek, Carson House, Anami Patel, John P DeVincenzo

Institutions: St. Jude Children's Research Hospital, University of Tennessee Health Science Center, Le Bonheur Children's Hospital, Atrium Health Wake Forest Baptist

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2797936891

FWCI:

Cites: 15

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Related to: 10