Re: Germline BRCA Mutations are Associated with Higher Risk of Nodal Involvement, Distant Metastasis, and Poor Survival Outcomes in Prostate Cancer
Year: 2013
Type: letter
Abstract: As we begin to better understand the influence of specific genetic mutations on prostate carcinogenesis, it is critically important to define the relationship of such mutations with disease outcome. To date, reports on the relationship between BRCA mutations and prostate cancer risk and outcome have been inconsistent, and at times contradictory. In this study the authors report a substantially worsened outcome for men with vs without germline BRCA1/2 mutations. Importantly these men presented with not only more advanced stage, but also higher Gleason score, suggesting phenotype rather than delay in diagnosis. In the setting of a recent report of a man undergoing prophylactic prostatectomy due to BRCA mutation this article offers guidance to the many men with known BRCA mutations who are unclear about the role of early intervention
Source: The Journal of Urology
Author: Samir S. Taneja
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2798337382