Year: 2018
Type: preprint
Abstract: TP53 functions as a tumor suppressor and has been described as the Guardian of the Genome. p53, the protein coded by TP53 predominantly binds regulatory response elements in introns of multiple target genes. We compared identical oligo subsequences in introns of multiple gene/transcripts including TP53, BRCA1, men1, PELP1, SET, HIF1A, ULBP1/2 and IRF3. Some identical oligo subsequences also contain the core response elements of known p53 binding sites or TP53 intronic, autoregulatory response elements and strongly correlate with known miRNAs. We describe how TP53 intronic autoregulatory response elements contribute their preference to p53 binding and propose a computational method to identify targets.
DOI: 10.1101/307959
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2798471912