Induced pluripotent stem cells
Year: 2013
Type: article
Abstract: Induced pluripotent stem cells (iPSCs) are pluripotent cells that have been “reprogrammed” from differentiated somatic cells. Most cells in the adult body are differentiated, that is, they have adopted a particular cellular fate and cannot generally turn into cells of any other type. Stem cells by contrast are able to generate a range of cell types, while pluripotent stem cells have the singular ability to generate any cell type in the body. “Reprogramming,” therefore, brings about the dramatic transformation of a somatic cell, whose fate is terminal and fixed, to a pluripotential cell that has the potential to generate any cell type in the body. Since this includes nerve cells, iPSCs present a means of generating human neurons in a tissue culture dish.
Authors: J. Wong, Nazish Sayed, John P. Cooke
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2799019400