Year: 2018
Type: review
Abstract: Obesity is an epidemic disease characterized by chronic low-grade inflammation associated with a dysfunctional fat mass. Adipose tissue is now considered an extremely active endocrine organ that secretes cytokine-like hormones, called adipokines, either pro- or anti-inflammatory factors bridging metabolism to the immune system. Leptin is historically one of most relevant adipokines, with important physiological roles in the central control of energy metabolism and in the regulation of metabolism-immune system interplay, being a cornerstone of the emerging field of immunometabolism. Indeed, leptin receptor is expressed throughout the immune system and leptin has been shown to regulate both innate and adaptive immune responses. This review discusses the latest data regarding the role of leptin as a mediator of immune system and metabolism, with particular emphasis on its effects on obesity-associated metabolic disorders and autoimmune and/or inflammatory rheumatic diseases.
Source: Frontiers in Physiology
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G1075404386, G1327936058, G165900816, G2017605187, Adipokinas y modulación neuroendocrina de la autofagia en el sistema musculo-esquelético; causas, consecuencias y potencial terapéutico., G2766614997, G3174281534, G3379205497, G3559709381, G4937468798, G6006292679, G6385464402, G654212923, G6587516864, G6696204527, Bioactive compounds from Olea europaea: investigation and application in food, cosmetic and pharmaceutical industry, Estudio de los factores de transcripción asociados a los cambios en la metilación del ADN durante la osteoblastogénesis y su papel en la diferenciación del osteoblasto., G8824911526, Papel de las adipokinas en la degeneración del disco intervertebral (DDIV): un nuevo enfoque fisiopatológico, G931469340
OpenAlex ID: W2799348059