Work

Central Nervous System Involvement of Rhabdomyosarcoma: A Single Institution Experience

Year: 2018

Type: article

Abstract: The incidence of central nervous system (CNS) involvement in patients with rhabdomyosarcoma (RMS) is low, and the outcome is dismal. We present a single institution analysis of CNS involvement of pediatric RMS. In 59 patients, the prevalence of CNS involvement was 11.9% (7 patients), higher than prior reports. Of the 6 deaths from disease, all had rapid progression, with a median survival of 14 days. The higher incidence could be secondary to treatment modifications or more sensitive detection. These findings are useful for decisions at the time of CNS involvement and could lead to modifications for future RMS clinical trials.

Source: Journal of Pediatric Hematology/Oncology

DOI: 10.1097/mph.0000000000001166

Authors: Daniel C. Moreira, Margaret E. Macy, Carrye R. Cost, Brian S. Greffe, Timothy P. Garrington

Institutions: Children's Hospital Colorado, University of Colorado Anschutz, University of Colorado Denver

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute