Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice
Work
Year: 2018
Type: article
Abstract: Rett syndrome (RTT) is the second leading cause of mental impairment in girls and is currently untreatable. RTT is caused, in more than 95% of cases, by loss-of-function mutations in the methyl CpG-bi... more
Source: Cell Reports
Authors Olga C. Jorge-Torres, Karolina Szczęsna, Laura M. Roa, Carmen Casal, Louisa González Somermeyer +12 more
Institutions Institut d'Investigació Biomédica de Bellvitge, Universitat de Barcelona, Ajuntament de L’Hospitalet, Maastricht University, Centre for Biomedical Network Research on Rare Diseases +2 more
Cites: 75
Cited by: 55
Related to: 10
FWCI: 2.989
Citation percentile (by year/subfield): 89.83
Subfield: Genetics
Domain: Life Sciences
Sustainable Development Goal Good health and well-being
Open Access status: gold
APC paid (est): $5,200
Grant IDS SAF2015-63568-R, SAF2014-56894-R