Year: 2018
Type: review
Abstract: Directed evolution was first applied to diverse libraries of DNA and RNA molecules a quarter century ago in the hope of gaining technology that would allow the creation of receptors, ligands, and catalysts on demand. Despite isolated successes, the outputs of this technology have been somewhat disappointing, perhaps because the four building blocks of standard DNA and RNA have too little functionality to have versatile binding properties, and offer too little information density to fold unambiguously. This review covers the recent literature that seeks to create an improved platform to support laboratory Darwinism, one based on an artificially expanded genetic information system (AEGIS) that adds independently replicating nucleotide “letters” to the evolving “alphabet”.
Source: Biomedicines
Authors: Elisa Biondi, Steven A. Benner
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,137
Awards: THE ALPHABET BIOGENESIS CONSORTIUM (ABC) WILL COMBINE SYNTHETIC BIOLOGY WITH IN VITRO AND IN VIVO EVOLUTION TECHNOLOGIES TO ADDRESS EACH ITEM IN THE, G6541015203, A CENTRAL QUESTION FACING NASA AS IT DESIGNS MISSIONS TO SEARCH FOR LIFE IN THE COSMOS ASKS HOW LIFE MIGHT BE RECOGNIZED IF IT WERE ACTUALLY ENCOUNTE, G903369309
OpenAlex ID: W2799781186