Work

Tuning conformation and properties of peptidomimetic backbones through dual N / C α -substitution

Year: 2018

Type: article

Abstract: We demonstrate that changing the backbone between peptides, peptoids and the underexplored dual N/Cα-substituted peptoids analogues allows for control over the preferred conformation of the intrinsically disordered biomimetic oligomers. The conformation tunability is directly probed using electron paramagnetic resonance (EPR), and is shown to manifest itself in differences in the nanoparticle-oligomer hybridization propensity.

Source: Chemical Communications

DOI: 10.1039/c8cc01356j

Authors: R. Kaminker, I. Kaminker, W. R. Gutekunst, Y. Luo, S. Lee, J. Niu, S. Han, C. J. Hawker

Institutions: University of California, Santa Barbara, University of California System

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Human Frontier Science Program, National Institutes of Health, Defense Advanced Research Projects Agency, National Institute of General Medical Sciences, Division of Materials Research

Awards: Development of Sequence Controlled Polymers for Antibacterial Therapeutics and Co, G3413345253, G4250104368

OpenAlex ID: W2800010932

FWCI: 0.8

Cites: 36

Cited by: 19

Related to: 10