LINE-1 retrotransposons and their impact on the human genome and in disease-causing mutations
Year: 2013
Type: dissertation
Abstract: Transposable elements (TEs) are DNA sequences capable of mobilizing and multiply within the genome of a host organism in both somatic and germ found in many species.In humans, comprise approximately 45% of the genetic material and, therefore, is not an insignificant fact, since although not part of the coding DNA (1.5%) are the largest source of variability among humans.TEs are divided into class I elements or retrotransposons (LTR as retroviruses and non-LTR as LINE, SINE and SVA) and class II or DNA transposons.This work is a review of TEs in humans, particularly LINE-1 retrotransposons (L1) and their impact on the human genome as well as the most characteristic disease-causing mutations
Author: S. Corrales Lorite
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2800203372