Year: 2018
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: Parkinson's disease (PD) is a multisystem movement disorder associated with sleep disturbance and depression. Sleep disturbances and depression severity share a bidirectional association. This association may be greater in individuals who are more vulnerable to the deleterious consequences of sleep disturbance and depression severity. We investigated whether the association between sleep disturbances and depression severity is greater in patients with PD than in matched controls (MC). MATERIALS AND METHODS: The study sample (N = 98) included 50 patients with idiopathic PD and 48 age-, race-, sex-, and education-matched controls. Sleep disturbances were assessed using self-reported total sleep time (TST) on the Pittsburgh Sleep Quality Index, the sleep item on the Beck Depression Inventory, 2nd ed. (BDI-II), and the Insomnia Severity Index total score. Depression severity was assessed using the BDI-II total score, excluding the sleep item. Spearman's correlations, chi-squared tests, and multiple regression were used to assess associations between sleep disturbances and depression severity in PD and MC. Fisher's Z transformation was used to test whether the association between sleep disturbances and depression severity was stronger in patients with PD. RESULTS: (98) = 0.46, p < .001, respectively. The association between shorter TST and depression severity was greater in patients with PD than it was in MC, p < .05. CONCLUSION: Short TST may be an important marker, predictor, or consequence of depression severity in patients with Parkinson's disease.
Source: Brain and Behavior
DOI: 10.1002/brb3.967
Authors: Daniel B. Kay, Jared J. Tanner, Dawn Bowers
Language: English
Topic: Sleep and related disorders
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $3,630
Funders: National Institutes of Health, National Institute on Aging, National Institute of Mental Health, National Institute of Nursing Research, National Institute of Neurological Disorders and Stroke, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Dissociating Components of Anhedonia: Pilot Behavioral and fMRI Data for the Effort Expenditure for Rewards Task, White Matter Connectivity and PD Cognitive Phenotypes, G3795379467, Mechanisms of airway protection dysfunction in Parkinson's disease, The Human Thalamocortical Network in Tourette Syndrome, G5749291741, Closing the Loop on Tremor: A Responsive Deep Brain Stimulator for the Treatment of Essential Tremor, Health Disparities in Osteoarthritis: Biological Aging, Stress, and Pain - Modulation by Resilience Factors, Determining Plasticity of Brain-Regulatory Mechanisms Related to Emotion Processing: A Neurofeedback Approach in Aging and Parkinson Disease, Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's Disease, Neuroimaging Biomarkers for Post-Operative Cognitive Decline in Older Adults, Interdisciplinary Training in Movement Disorders and Neurorestoration
OpenAlex ID: W2800234811