Antimicrobial Activity of Mono- and Di-Methyl Substituted Benzhydrols and Benzophenones In Vitro
Year: 2007
Type: article
Abstract: Twelve compounds of mono methyl and symmetrical dimethyl substituted benzhydrol and benzophenone were synthesized using standard synthetic procedures and screened for possible antimicrobial activity against thirteen known Gram-positive and Gram-negative bacteria, as well as two yeasts. Most benzhydrol and benzophenone derivatives under investigation demonstrated some antimicrobial activity, with ortho-methylbenzophenone, dapsone, meta-dimethylbenzophenone, and para-dimethylbenzyhydrol showing the greatest inhibition. Only four compounds, ortho-methylbenzhydrol, para-methylbenzhydrol, para-methylbenzophenone, and para-diaminobenzophenone, completely lacked antimicrobial activity. An Analysis of Variance (ANOVA) showed a significant difference between both the microorganisms and the chemical compounds used, which may provide insight into novel compounds to combat infections in humans and animals.
Authors: Margaret J. Lange, Anna R. Oller, Somnath Sarkar
Institution: University of Central Missouri
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2800242936