OpenAlex | Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells

Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells

Work

Year: 2018

Type: article

Abstract: Novel pyrazole-based EZH2 inhibitors have been prepared through a molecular pruning approach from known inhibitors bearing a bicyclic moiety as a central scaffold. The hit compound 1o ( N -((4,6-dimet... more

Source: Philosophical Transactions of the Royal Society B Biological Sciences

Authors Paolo Mellini, Biagina Marrocco, Diana Borovika, Lucia Polletta, Ilaria Carnevale +8 more

Institutions Sapienza University of Rome, Latvijas Organiskās Sintēzes Institūts, Istituto Pasteur

Cites: 41

Cited by: 22

Related to: 10

FWCI: 1.138

Citation percentile (by year/subfield): 82.68

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Sustainable Development Goal Good health and well-being

Open Access status: bronze