Work

Modeling of canonical and C2′- O -thiophenylmethyl modified hexamers of RNA. Insights into the nature of structural changes and thermal stability

Year: 2018

Type: article

Abstract: Modification of the C2′- O -position with thiophenylmethyl groups on both strands leads to thermal stabilization of the duplex. Predicting the effects that modifications will have on structure of RNA is of importance in the development of new RNA technologies.

Source: New Journal of Chemistry

DOI: 10.1039/c8nj01739e

Authors: Yannick Kokouvi Dzowo, Carly Wolfbrandt, Marino J. E. Resendiz, Haobin Wang

Institution: University of Colorado Denver

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, University of Colorado Denver, Division of Chemistry

Awards: G4501007227, Developing the multilayer multiconfiguration time-dependent Hartree theory