Work

Response to Long-term Vitamin D Therapy for Bone Disease in Children With Sickle Cell Disease

Year: 2018

Type: article

Abstract: Patients with sickle cell disease (SCD) are at risk for bone fragility from multiple factors including vitamin D deficiency. To date, no studies have evaluated the efficacy and safety of long-term vitamin D therapy for bone disease in children with SCD. We report a cohort of 4 children with SCD found to have severe vitamin D deficiency, secondary hyperparathyroidism, and abnormal bone mineral density treated with monthly high-dose oral cholecalciferol over 2 years. All patients exhibited a positive response to therapy without hypervitaminosis D or hypercalcemia. Further studies are needed to standardize guidelines for optimal vitamin D dosing and prevention of toxicity.

Source: Journal of Pediatric Hematology/Oncology

DOI: 10.1097/mph.0000000000001155

Authors: Kristen M. Williams, Margaret T. Lee, Maureen Licursi, Gary M. Brittenham, Ilene Fennoy

Institution: Columbia University Irving Medical Center

Language: English

Topic: Vitamin D Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Food and Drug Administration, National Institute of Diabetes and Digestive and Kidney Diseases