Year: 2018
Type: review
Abstract: Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with differentiating divisions that sustain continuous sperm production. Rodent stem and progenitor spermatogonia are described by their clonal arrangement in the seminiferous epithelium (e.g., Asingle, Apaired or Aaligned spermatogonia), molecular markers (e.g., ID4, GFRA1, PLZF, SALL4 and others) and most importantly by their biological potential to produce and maintain spermatogenesis when transplanted into recipient testes. In contrast, stem cells in the testes of higher primates (nonhuman and human) are defined by description of their nuclear morphology and staining with hematoxylin as Adark and Apale spermatogonia. There is limited information about how dark and pale descriptions of nuclear morphology in higher primates correspond with clone size, molecular markers or transplant potential. Do the apparent differences in stem cells and spermatogenic lineage development between rodents and primates represent true biological differences or simply differences in the volume of research and the vocabulary that has developed over the past half century? This review will provide an overview of stem, progenitor and differentiating spermatogonia that support spermatogenesis; identifying parallels between rodents and primates where they exist as well as features unique to higher primates.
Source: Stem Cell Research
Authors: Adetunji P. Fayomi, Kyle E. Orwig
Institutions: University of Pittsburgh, Magee-Womens Research Institute
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,360
Awards: Improving Fertility Preservation in Boys with Cancer, Preserving Male Fertility After Cancer Therapy, New Fertility Preserving Option for Male Cancer Survivors, Characterization of male germline stem cells in a rhesus model of infertility, Cellular Mechanisms of Chemotherapy-induced Male Infertility: Stem Cell or Niche?
OpenAlex ID: W2800761804