Work

Raman fingerprints of amyloid structures

Year: 2018

Type: article

Abstract: Structural differences in pathological and functional amyloid fibrils have been investigated by Raman microspectroscopy. Second-derivative analyses of amide-I and amide-III bands distinguish parallel in-register β-sheets from a β-solenoid. Further, spatially resolved Raman spectra reveal molecular heterogeneity in amyloid structures.

Source: Chemical Communications

DOI: 10.1039/c8cc03217c

Authors: Jessica D. Flynn, Jennifer C. Lee

Institutions: National Institutes of Health, National Heart, Lung, and Blood Institute

Language: English

Topic: Spectroscopy Techniques in Biomedical and Chemical Research

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: G4041794682, G9000117099