Work

Medical and Semi-surgical Treatments for Fuchs Endothelial Corneal Dystrophy

Year: 2018

Type: article

Abstract: Unraveling the genetic mechanisms of Fuchs endothelial corneal dystrophy has opened new possibilities for future targeted medical therapy of the disease. Until these possibilities mature, regenerative semi-surgical approaches by cell injection or cell sheet transfer could help expand the donor pool, and possibly enable autologous transplantation. Descemet membrane stripping alone and acellular Descemet membrane transfer are more immediate surgical approaches that could be temporary treatments in some patients, though there is a lack of understanding of the factors that predict success for these procedures. Regardless of approach, clinical trials will be necessary, and clinicians should therefore try to standardize their methods of assessing disease severity and the outcomes of intervention.

Source: Klinische Monatsblätter für Augenheilkunde

DOI: 10.1055/a-0577-7953

Authors: Katrin Wacker, Keith Baratz, Michael Fautsch, Sanjay Patel

Institutions: Mayo Clinic, University of Freiburg

Language: English

Topic: Corneal surgery and disorders

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Eye Institute