Work

Targeting protein biotinylation enhances tuberculosis chemotherapy

Year: 2018

Type: article

Abstract: Inhibitors of biotin protein ligase and protein biotinylation in Mycobacterium tuberculosis act synergistically with the drug rifampicin, potentially shortening tuberculosis treatment.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.aal1803

Authors: Divya Tiwari, Sae Woong Park, Maram M. Essawy, Surendra Dawadi, Alan Mason, Madhumitha Nandakumar, Matthew Zimmerman, Marizel Mina, Hsin Pin Ho, Curtis A. Engelhart, Thomas Ioerger, James C. Sacchettini, Kyu Rhee, Sabine Ehrt, Courtney C. Aldrich, Véronique Dartois, Dirk Schnappinger

Institutions: Weill Cornell Medicine, University of Minnesota, Rutgers, The State University of New Jersey, Rutgers New Jersey Medical School, Texas A&M University

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Allergy and Infectious Diseases

Awards: Tri-Institutional TB Research Unit: Persistence and Latency, Biotin synthesis and biotin ligation in Mtb, G2710720576

OpenAlex ID: W2801243725

FWCI: 3.419

Cites: 41

Cited by: 34

Related to: 10