Year: 2018
Type: review
Abstract: Cancer patients experience a four-fold increase in thrombosis risk, indicating that cancer development and progression are associated with platelet activation. Xenograft experiments and transgenic mouse models further demonstrate that platelet activation and platelet-cancer cell interaction are crucial for cancer metastasis. Direct or indirect interaction of platelets induces cancer cell plasticity and enhances survival and extravasation of circulating cancer cells during dissemination. In vivo and in vitro experiments also demonstrate that cancer cells induce platelet aggregation, suggesting that platelet-cancer interaction is bidirectional. Therefore, understanding how platelets crosstalk with cancer cells may identify potential strategies to inhibit cancer metastasis and to reduce cancer-related thrombosis. Here, we discuss the potential function of platelets in regulating cancer progression and summarize the factors and signaling pathways that mediate the cancer cell-platelet interaction.
DOI: 10.3390/ijms19041246
Authors: Shike Wang, Zhenyu Li, Ren Xu
Institutions: University of Kentucky, Markey Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: G2800195642, Systemic delivery of miR-29 for basal-like breast cancer treatment, Roles of RORalpha in breast cancer development and progression, ULTRASTABLE NONTOXIC RNA NANOPARTICLES FOR TARGETING TRIPLE-NEGATIVE BREAST CANCER STEM CELLS, G4119534169, G4786076345, G6406686574, Roles of Hsp47 in breast cancer progression
OpenAlex ID: W2801252094