Work

Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer

Year: 2018

Type: article

Source: Oncogene

DOI: 10.1038/s41388-018-0289-x

Authors: Kyle Knickelbein, Jingshan Tong, Dongshi Chen, Yi-Jun Wang, Sandra Misale, Alberto Bardelli, Jian Yu, Lin Zhang

Institutions: University of Pittsburgh, UPMC Hillman Cancer Center, Memorial Sloan Kettering Cancer Center, Candiolo Cancer Institute, University of Turin

Language: English

Topic: Colorectal Cancer Treatments and Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Cotswold Foundation, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center, Signature-Directed, Sequential Delivery of Radiation Mitigators, PUMA-mediated apoptosis in human cancer cells, Bid-mediated killing of oncogenic stem cells in chemoprevention, Translation addiction and targeting in colon cancer, Novel Mcl-1 inhibitors for overcoming therapeutic resistance in colorectal cancer, Intestinal Stem Cell Survival and Renewal Coordinately Regulated by PUMA and p21, Role of Mcl-1 degradation in colorecal cancer therapy, Intestinal Stem Cell Consortium Coordinating Center, Cancer Center Support Grant, Cancer Center Support Grant

OpenAlex ID: W2801274882

FWCI: 2.067

Cites: 45

Cited by: 33

Related to: 10