Unraveling the molecular mechanisms of thermo-responsive properties of silk-elastin-like proteins by integrating multiscale modeling and experiment
Year: 2018
Type: article
Abstract: molecules at high concentrations impeded their structural transition at high temperatures that drastically reduced the degree of deswelling through extensive suppression of the structural shuffling and the trapping of the molecules in high potential energy states due to inter-molecular constraints. This integrative experimental and computational understanding of the thermal response in single molecules of SELPs and their crosslinked networks should lead to further improvements in the properties of SELP hydrogels through predictive designs and their wider applications in biomaterials and tissue engineering.
Source: Journal of Materials Chemistry B
DOI: 10.1039/c8tb00819a
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Funders: National Science Foundation, U.S. Department of Defense, Agency for Science, Technology and Research, National Supercomputing Centre Singapore, National Institutes of Health, Efficacy and Mechanism Evaluation Programme, Office of Naval Research, National Institute of Biomedical Imaging and Bioengineering
OpenAlex ID: W2801522763