The Peroxin Pex34p Functions with the Pex11 Family of Proteins to Regulate the Peroxisome Population in the Yeast Saccharomyces cervisiae
Year: 2012
Type: dissertation
Abstract: Peroxisomes are highly dynamic organelles that change in size and number in response to both intra- and extracellular cues. Peroxisome growth and division are controlled by the import of matrix proteins and by a specialized divisional machinery that includes peroxisome-specific factors, such as members of the Pex11 protein family, and general organelle divisional factors, such as the dynamin-related protein Vps1p. Here we show that Pex34p is a peroxisomal integral membrane protein that acts independently and together with the Pex11 protein family members Pex11p, Pex25p and Pex27p to control the peroxisome populations of cells under conditions of both peroxisome proliferation and constitutive peroxisome division. Pex34p can act as a positive effector of peroxisome division but requires the Pex11 family proteins. Our addition of Pex34p to the repertoire of proteins involved in regulating peroxisome division emphasizes the necessity of cells to strictly regulate their peroxisome populations.
DOI: 10.7939/r3711r
Author: Tower, Robert J
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2801670813