Non-Coding RNA Mediated Regulation of Allogeneic T Cell Responses After Hematopoietic Transplantation
Year: 2018
Type: review
Abstract: Allogeneic bone marrow transplantation (BMT) is an effective therapy for several malignant and non-malignant disorders. The precise control of allogeneic T cells is critical for successful outcomes after BMT. The mechanisms governing desirable (graft-versus-leukemia) versus undesirable (graft-versus-host disease) allogeneic responses remain incompletely understood. Non-coding RNAs (ncRNA) are controllers of gene expression that fine-tune cellular responses. Multiple microRNAs (miRNAs), a type of ncRNA, have recently been shown to influence allogeneic T cell responses in both murine models and clinically. Here, we review the role of various miRNAs that regulate T cell responses, either positively or negatively, to allo-stimulation and highlight their potential relevance as biomarkers and as therapeutic targets for improving outcomes after allogeneic BMT.
Source: Frontiers in Immunology
Authors: Daniel Peltier, Pavan Reddy
Institutions: University of Michigan, Michigan Medicine, U-M Rogel Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G1243127772, G161014721, Role of noncoding RNA in Regulating GVHD, G2537228941, G3848375233, Targeting antigen presentation to enhance GVL responses after Bone Marrow Transpl, Development of novel strategy for treatment of steroid refractory GVHD, G5605388423, Targeting Novel DAMP mediated signaling pathways to mitigate GVHD, G7482839210, Cellular and molecular mechanisms of target tissue resistance for mitigating GVHD severity, G8510110464, Advancing Child Health Through Cellular and Molecular Biology, Boxer Training Program in Hematology
OpenAlex ID: W2801684784