Year: 2018
Type: article
Abstract: EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt.' Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it.
Source: Molecular Autism
Authors: the EU-AIMS LEAP group, Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K. Buitelaar, Eva Loth, Declan G. M. Murphy, Will Spooren, Sven Bölte
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,990
Funders: Autism Speaks, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, AstraZeneca, GlaxoSmithKline, F. Hoffmann-La Roche, Brandeis University, European Federation of Pharmaceutical Industries and Associations, National Institute for Health and Care Research, University of Oxford, European Commission, Lundbeckfonden, Innovative Medicines Initiative, Servier, H. Lundbeck A/S, Desitin Arzneimittel, Lilly Deutschland, Medical Research Council, H2020 European Research Council, FP7 Ideas: European Research Council, Cilag
Awards: G1073258374, G1732308444, G1743590445, NIHR Senior Investigator Award, G2902570791, G2996863859, G3031778124, G3207356259, MRC Centre for Neurodevelopmental Disorders, G393177772, NIHR Senior Investigator Award, European Autism Interventions - A Multicentre Study for Developing New Medications, G5702163051, G60524263, G8563726104, G8864298512
OpenAlex ID: W2801888814