Synthesis and Preliminary Anti-bovine Viral Diarrhea Virus (BVDV) Activity Evaluation of Morpholine Nucleoside Analogues and Their Sulfonamide Derivatives
Year: 2018
Type: article
Abstract: A series of morpholine nucleoside analogues were synthesized starting from ribonucleosides, and then the morpholine nucleoside sulfonamide derivatives were obtained by treated with N-acetylsulfanilyl chloride.The obtained compounds were confirmed by HRMS, 1 H NMR and 13 C NMR spectral analysis.The bovine kidney cells infected with bovine viral diarrhea virus (BVDV) were used as models to screen the antiviral activity of the target compounds.But the results did not show desired potent antiviral activity.Keywords nucleoside analogue; morpholine nucleoside; sulfonamides derivative; anti-BVDV activity 随着现代社会生活节奏的加快, 癌症、病毒性疾病 时刻威胁着人类的健康, 研制高效、低毒、低耐药性的 药物成为当今医药领域科研人员刻不容缓的使命.核苷 类药物目前用于治疗多种病毒性感染疾病如乙肝病毒 (HBV)、丙肝病毒(HCV)和艾滋病病毒(HIV)等, 一些核 苷也用于治疗肿瘤 [1,2] .磺胺类药物是以对氨基苯磺酰 胺(简称磺胺)为基本结构的衍生物的总称 [3,4] , 是应用最 早的一类化学合成抗菌药物.随着人们对磺胺类药物的 深入研究, 发现修饰磺胺母体的磺酰胺基、苯胺基可以 改善磺胺类药物的理化性质, 增强其潜在生物活性, 同 时还可赋予其一些新的生物功能.其中含氮杂环尤其是 嘧啶环修饰的磺胺类药物显示出卓越的药用价值.例如 治
Authors: Yingchun Hua, Bin He, Zhiyan Qin, Song Wang, Huiping Liu, Fengwu Liu
Institution: Zhengzhou University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2801933500