Work

The distinct structural preferences of tau protein repeat domains

Year: 2018

Type: article

Abstract: The tau fibrillar structures from the brain of an Alzheimer's patient have a core with a C-shaped motif of the third and fourth repeat domains (R3-R4). Our simulations indicated that the C-shaped motif is only stable for R3-R4, while R1-R2 tends to be linear in shape. These two structural motifs appear in the most stable K18 protofilament. Heparin can further stabilize the C-shaped R3-R4 motif, but not other repeats.

Source: Chemical Communications

DOI: 10.1039/c8cc01263f

Authors: Xuhua Li, Xuewei Dong, Guanghong Wei, Martin Margittai, Ruth Nussinov, Buyong Ma

Institutions: Fudan University, Collaborative Innovation Center of Advanced Microstructures, State Key Laboratory of Surface Physics, University of Denver, Tel Aviv University, National Cancer Institute, Leidos Biomedical Research Inc. (United States)

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: Council for Chemical Research, National Natural Science Foundation of China, National Institutes of Health, National Cancer Institute

Awards: Protein Structure, Stability, and Amyloid Formation, G3503792436, G386607036, 天然小分子化合物抑制固有无序蛋白聚集的微观机理研究, G5888954722

OpenAlex ID: W2801950316

FWCI: 2.058

Cites: 22

Cited by: 42

Related to: 10