Year: 2016
Type: other
Abstract: Aging is a major risk factor for numerous diseases in modern world. The process of aging can be influenced by intern and extern aspects. It was demonstrated that caloric restriction can delay aging reducing age-related diseases and increasing life span. Caloric restriction’s increase in life span seems to be mediated by several mechanisms such as insulin/IGF-1 signalling, autophagy stimulation, PCG-1α, sirtuins, AMPK and Neuropeptide Y. The difficulty in maintaining a caloric restriction with optimal nutrition (CRON) diet encouraged the search for caloric restriction mimetics, drugs capable of mimicking caloric restriction benefits and increase life span. In the present work we describe several compounds that have emerged as potential caloric restriction mimetics inducing overlapping mechanisms to caloric restriction. Among these are included 2-deoxy-D-glucose (glycolytic inhibitor), Metformin (biguanide), Pegvisomant and Octreoside (IGF-1 antagonist), Resveratrol (SIRT-1 agonist) and Neuropeptide Y.
Author: Maria Inês Branco Abegão
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2801961664