Work

Multicomponent peptide assemblies

Year: 2018

Type: review

Abstract: Self-assembled peptide nanostructures have been increasingly exploited as functional materials for applications in biomedicine and energy. The emergent properties of these nanomaterials determine the applications for which they can be exploited. It has recently been appreciated that nanomaterials composed of multicomponent coassembled peptides often display unique emergent properties that have the potential to dramatically expand the functional utility of peptide-based materials. This review presents recent efforts in the development of multicomponent peptide assemblies. The discussion includes multicomponent assemblies derived from short low molecular weight peptides, peptide amphiphiles, coiled coil peptides, collagen, and β-sheet peptides. The design, structure, emergent properties, and applications for these multicomponent assemblies are presented in order to illustrate the potential of these formulations as sophisticated next-generation bio-inspired materials.

Source: Chemical Society Reviews

DOI: 10.1039/c8cs00115d

Authors: Danielle M. Raymond, Bradley L. Nilsson

Institution: University of Rochester

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, Division of Materials Research

Awards: Novel Peptide/siRNA Nanoparticles for Treatment of Acute Lung Injury, G5657816298