Intestinal Integrity Biomarkers in Early Antiretroviral-Treated Perinatally HIV-1–Infected Infants
Year: 2018
Type: article
Study design: Observational Study
Abstract: Intestinal fatty acid binding protein (iFABP) levels did not differ between human immunodeficiency virus type 1 (HIV-1)- infected infants and uninfected infants exposed to HIV-1, but those who breastfed had substantially lower levels. Zonulin levels increased from 3 to 5.3 months of age with perinatal acquisition of HIV-1 despite early antiretroviral treatment. Biomarkers of intestinal integrity (ie, iFABP and zonulin) were compared in 56 HIV-1-positive African infants who received early antiretroviral treatment and 53 HIV-1-exposed but uninfected (HEU) controls. Despite heightened inflammation and immune activation in HIV-positive infants, iFABP and zonulin levels at 3 months of age were not different from those in HEU infants and largely were not correlated with inflammatory and immune activation biomarkers. However, zonulin levels increased and became significantly higher in HIV-positive infants as compared to HEU infants by 5 months of age, despite viral suppression due to antiretroviral treatment. These findings have implications for intestinal integrity biomarker profiling in perinatal HIV-1 infection.
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Funders: GlaxoSmithKline, Johns Hopkins University, International Maternal Pediatric Adolescent AIDS Clinical Trials Network, National Institutes of Health, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1524427083, G3262353703, G3342746445, G4853082081, Statistical and Data Management Center for the AIDS Clinical Trials Group, Early Antiretroviral Therapy and HIV Remission in Perinatal Infection, G8536071820, SDMC - IMPAACT Leadership Group, UZ-UCSF CTU, International Maternal, Adolescent and Pediatric Therapeutics Clinical Trials Network, Botswana-Harvard T.H. Chan School of Public Health AIDS Initiative Partnership CTU, The Johns Hopkins Center for AIDS Research (JHU CFAR), Statistical and Data Management Center (SDMC), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG), IMPAACT Leadership Group, Research Training in Pediatric Infectious Diseases
OpenAlex ID: W2802344580