Work

Increased Systemic Inflammation and Gut Permeability Among Women With Treated HIV Infection in Rural Uganda

Year: 2018

Type: article

Study design: Observational Study

Abstract: In a cohort of human immunodeficiency virus (HIV)-infected individuals and age- and sex-matched HIV-uninfected comparators, we assessed soluble CD14 (sCD14), sCD163, interleukin 6, intestinal fatty acid binding protein (IFAPB), and high-sensitivity C-reactive protein (hs-CRP) levels. The median age was 51 years. Among HIV-positive individuals, the median antiretroviral therapy (ART) duration was 7 years, the median CD4+ T-cell count was 433 cells/μL, and 86% had an undetectable viral load. Although HIV-positive individuals had higher sCD14, IFABP, and hs-CRP levels, we found evidence of interaction by sex, such that HIV-positive women had greater differences from HIV-negative women, compared with differences between HIV-positive men and HIV-negative men. In models restricted to HIV-positive individuals, women had higher levels of all 5 biomarkers than men.

Source: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jiy244

Authors: Mark J Siedner, Markella Zanni, Russell P Tracy, Douglas S Kwon, Alexander C Tsai, Bernard Kakuhire, Peter W Hunt, Samson Okello

Institutions: Harvard University, Mbarara University of Science and Technology, Massachusetts General Hospital, University of Vermont, University of California, San Francisco, University of Virginia

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1184869378, Polycyclic aromatic hydrocarbons exposure and dietary risk of Esophageal squamous cell carcinoma in Uganda, G3649723969, G5920980811, Developing Research At The Interface Of HIV And Aging, Epidemiology of atherosclerosis among older-age individuals with HIV in Uganda, The enteric microbiome in treated and progressive HIV infection, G9000024751, G9000054876, G9000185809, G9000268975, G97119092

OpenAlex ID: W2802393893

FWCI: 2.872

Cites: 18

Cited by: 51

Related to: 10