Work

Substrate mediated redox partner selectivity of cytochrome P450

Year: 2018

Type: article

Abstract: Investigating the interplay between cytochrome-P450 and its redox partners (CPR and cytochrome-b5) is vital for understanding the metabolism of most hydrophobic drugs. Dynamic structural interactions with the ternary complex, with and without substrates, captured by NMR reveal a gating mechanism for redox partners to promote P450 function.

Source: Chemical Communications

DOI: 10.1039/c8cc02525h

Authors: Katherine A. Gentry, Meng Zhang, Sang-Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy

Institutions: University of Michigan, Michigan Medicine, Ann Arbor VA Medical Center

Language: English

Topic: Metal-Catalyzed Oxygenation Mechanisms

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: Investigation of Membrane-Bound Cytochromes-P450-b5 Interactions