Anti-CA15.3 and Anti-CA125 Antibodies and Ovarian Cancer Risk: Results from the EPIC Cohort
Year: 2018
Type: article
Study design: Observational Study
Abstract: Background: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3, and CA125, and generate antibodies against them, but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined. Methods: CA15.3, CA125, and IgG1 antibodies against them were measured in 806 women who developed EOC and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression. Results: In controls, lower antibodies against both mucins were associated with current smoking; and, in postmenopausal women, higher levels with longer oral contraceptive use and later-age-at and shorter-interval-since last birth. Lower anti-CA15.3 antibodies were associated with higher body mass and, in premenopausal women, more ovulatory cycles. Higher anti-CA15.3 and anti-CA125 antibodies were associated with higher risk for mucinous EOC occurring ≥ 3 years from enrollment. Long-term risk for serous EOC was reduced in women with low CA125 and high anti-CA125 antibodies relative to women with low concentrations of both. Conclusions: We found general support for the hypothesis that anti-mucin antibody levels correlate with risk factors for EOC. Antibodies alone or in combinations with their antigen may predict longer term risk of specific EOC types. Impact: Anti-CA125 and anti-CA15.3 antibodies alone or in perspective of antigens may be informative in the pathogenesis of EOC subtypes, but less useful for informing risk for all EOC. Cancer Epidemiol Biomarkers Prev; 27(7); 790–804. ©2018 AACR.
Authors: Daniel W. Cramer, Raina N. Fichorova, Kathryn L. Terry, Hidemi Yamamoto, Allison F. Vitonis, Eva Ardanaz, Dagfinn Aune, Heiner Boeing, Jenny Brändstedt, Marie-Christine Boutron-Ruault, Maria-Dolores Chirlaque, Miren Dorronsoro, Laure Dossus, Eric J. Duell, Inger T. Gram, Marc Gunter, Louise Hansen, Annika Idahl, Theron Johnson, Kay-Tee Khaw, Vittorio Krogh, Marina Kvaskoff, Amalia Mattiello, Giuseppe Matullo, Melissa A. Merritt, Björn Nodin, Philippos Orfanos, N. Charlotte Onland-Moret, Domenico Palli, Eleni Peppa, J. Ramón Quirós, Maria-Jose Sánchez-Perez, Gianluca Severi, Anne Tjønneland, Ruth C. Travis, Antonia Trichopoulou, Rosario Tumino, Elisabete Weiderpass, Renée T. Fortner, Rudolf Kaaks
Institutions: Brigham and Women's Hospital, Harvard University, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Imperial College London, German Institute of Human Nutrition, Lund University, Skåne University Hospital, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Biogipuzkoa Health Research Institute, Centre international de recherche sur le cancer, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, UiT The Arctic University of Norway, Danish Cancer Society, Umeå University, German Cancer Research Center, University of Cambridge, Fondazione IRCCS Istituto Nazionale dei Tumori, Federico II University Hospital, University of Naples Federico II, Italian institute for Genomic Medicine, University of Turin, National and Kapodistrian University of Athens, Hellenic Health Foundation, University Medical Center Utrecht, Istituto per lo Studio e la Prevenzione Oncologica, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Andalusian School of Public Health, University of Oxford, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: World Health Organization, Deutsches Krebsforschungszentrum, Fujirebio US, Cancer Research UK, National Institute for Health and Care Research, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Ligue Contre le Cancer, Vetenskapsrådet, NordForsk, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Hellenic Health Foundation, National Institutes of Health, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, National Cancer Institute
Awards: G1055973116, G1075502044, G1090603134, G1192877484, G1208621354, G1241080153, G1265254713, G1274701479, G1318397260, G1344656563, G1559294051, G172151099, G1767199718, G1788285306, G1788645866, G1907752718, G1952936224, G1993546569, G2072618322, G2131326840, G2149779140, G2149865848, G2216207056, G2235605558, G2257231888, G2336049343, G2372467518, G2409987178, G2539064604, G2561548287, G2572521044, G2663613759, G273148272, G2742323354, G2841678936, G2871896171, G29072894, G2924980845, G3010599472, G3014481958, G3049845011, G3077395769, G3149246560, G3170664214, G3189789075, G3216658785, G331404038, G3452641779, G3461390129, G3544161537, G3675143906, G3747421453, G375319704, G3816092139, G382879149, G3980646122, G4012977212, G4015156572, G4041385912, G4049848471, G4081633361, G4089957676, G4213141252, G423622538, G4303038735, G43956866, G4473162978, Health of vegetarians, G459595259, G4682079261, G4811780622, G4879533352, G490534113, G4913827001, G5004963360, G5047213743, G5119219000, G5375816427, G5406065712, G5456958854, G5578953934, G558017500, G5651954792, G569447510, G569908600, G5706284561, G5750710683, G5868006920, G5897142711, G5932924763, G5990830295, G6085534252, NIHR Senior Investigator Award, G6212483348, G6238616637, G6264211199, G6305665937, G6320156643, G640002926, G6442500046, G657255654, G6594529311, G6631454880, G6723261869, G6820515600, G6960682749, G7022277044, G7025202487, G7040807446, G7306252069, G7426181285, G7447125227, G7600088736, G7624991799, G7646326732, G769817697, G7853538257, G7939399614, G7972317318, G7993655663, G8012318887, G8050896463, G817390530, G8279237360, G8331243404, G8374761964, G8407261631, G848473175, G8508326818, G8525262851, G8716998914, G876765158, G8867963557, G8869854444, G8959392569, G8978728421, G9000070544, G9000344513
OpenAlex ID: W2802581723