Age of Infection with Kaposi Sarcoma–Associated Herpesvirus and Subsequent Antibody Values Among Children in Uganda
Year: 2018
Type: article
Study design: Observational Study
Abstract: We investigated associations between Kaposi sarcoma-associated herpesvirus (KSHV) seroconversion age and KSHV antibody values in Ugandan children. Every annual delay in KSHV seroconversion age was associated with a reduction of 19% (P < 0.0001) in K8.1 and 27% (P < 0.0001) in ORF73 antibody values at 6 years of age. Early infection may be an important risk factor for KSHV pathogenesis and viral shedding in saliva, leading to transmission.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,649
Funders: Wellcome Trust, Children’s Hospital of Wisconsin Research Institute, Children's Hospital Foundation, Murdoch Children's Research Institute, Royal Children's Hospital Foundation, Australian Government, State Government of Victoria, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Cancer Institute
Awards: The impact of helminths on the response to immunisation and on the incidence of infection and disease in childhood in Uganda., G2468189520, G3503792436, G3588101915, Understanding the shared determinants and causal pathways of early life infection, inflammation and atherosclerosis., G386607036, The impact of helminths on the response to immunisation and on susceptibility to infectious diseases in childhood in Uganda., G5888954722, G6374948078, G7853697249, A novel paradigm for immunity and vaccine development against group A streptococcus
OpenAlex ID: W2802600415