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Hematotoxicity of intratracheally instilled arsenic trioxide in rats

Year: 2018

Type: article

Abstract: The study aimed to investigate the correlation between concentration of inhaled arsenic trioxide and dynamic changes in hematotoxicity in rats. Wistar rats were randomly divided into four study groups that were treated with saline (control) or arsenic trioxide at a low (0.1 mg/mL), medium (1 mg/mL), or high (10 mg/mL) dose by intratracheal instillation. Blood samples were collected for analysis at 6, 12, 24, 48, and 72 h after exposure. Compared with the control group, intratracheal instillation of arsenic trioxide affected hematopoietic differentiation in rats, leading to blood cell changes that were related to observation time and concentration.

Source: Infection International/Infection International (Electronic Edition)

DOI: 10.1515/ii-2017-0163

Authors: Mingxing Su, Congsong Sun, Haiying Wang, Chunyu Yuan, Ruixia Guo, Yajie Liang, Chao Liu, Qiang Wang

Language: English

Topic: Immunotoxicology and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2802667810

FWCI: 0.087

Cites: 28

Cited by: 2

Related to: 10