Year: 2018
Type: review
Abstract: In light of the limited efficacy of current treatments for cardiac regeneration, tissue engineering approaches have been explored for their potential to provide mechanical support to injured cardiac tissues, deliver cardio-protective molecules, and improve cell-based therapeutic techniques. Injectable hydrogels are a particularly appealing system as they hold promise as a minimally invasive therapeutic approach. Moreover, injectable acellular alginate-based hydrogels have been tested clinically in patients with myocardial infarction (MI) and show preservation of the left ventricular (LV) indices and left ventricular ejection fraction (LVEF). This review provides an overview of recent developments that have occurred in the design and engineering of various injectable hydrogel systems for cardiac tissue engineering efforts, including a comparison of natural versus synthetic systems with emphasis on the ideal characteristics for biomimetic cardiac materials.
Source: Macromolecular Bioscience
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: bronze
Awards: G1131312871, Rocky Mountain Neurological Disorders Core Center, G4921130661, A comprehensive approach to the treatment of heart failure with reduced ejection fraction (HFrEF), Colorado Clinical and Translational Sciences Institute, Molecular Epidemiology of Dilated Cardiomyopath, A biomimetic reverse thermal gel for the treatment of myocardial infarction, Engineered biomimetic injectable system towards cardiac repair, Colorado Clinical and Translational Science Institute (UL1)
OpenAlex ID: W2802784789