Work

Weakly-coordinating N -oxide and carbonyl groups for metal-catalyzed C–H activation: the case of A-ring functionalization

Year: 2018

Type: article

Abstract: Compounds featuring weakly-coordinating N-oxides or carbonyl groups, as for instance, quinoline N-oxide and quinonoid systems represent important structural scaffolds with potential biological activities. Due to their biological importance, significant efforts have been devoted to devise robust methods for their step-economical preparation. Among these approaches, the C-H activation strategy has emerged as a powerful, versatile and efficient tool in molecular sciences. This feature article summarizes recent key advances in transition-metal-catalyzed C-H functionalization for A-ring functionalization of heterocyclic and quinoidal compounds by challenging weakly-coordinating entities, published prior to May 2018.

Source: Chemical Communications

DOI: 10.1039/c8cc03147a

Authors: Eufrânio N. da Silva Júnior, Guilherme A. M. Jardim, Roberto S. Gomes, Yu-Feng Liang, Lutz Ackermann

Institutions: Universidade Federal de Minas Gerais, Harvard University, Universidade Federal da Grande Dourados, University of Göttingen

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid