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Role of metabolism in cancer cell radioresistance and radiosensitization methods

Year: 2018
Type: article
Abstract: BACKGROUND: Radioresistance is a major factor leading to the failure of radiotherapy and poor prognosis in tumor patients. Following the application of radiotherapy, the activity of various metabolic pathways considerably changes, which may result in the development of resistance to radiation. MAIN BODY: Here, we discussed the relationships between radioresistance and mitochondrial and glucose metabolic pathways, aiming to elucidate the interplay between the tumor cell metabolism and radiotherapy resistance. In this review, we additionally summarized the potential therapeutic targets in the metabolic pathways. SHORT CONCLUSION: The aim of this review was to provide a theoretical basis and relevant references, which may lead to the improvement of the sensitivity of radiotherapy and prolong the survival of cancer patients.
DOI: 10.1186/s13046-018-0758-7
Authors: Le Tang, Fang Wei, Yingfen Wu, Yi He, Lei Shi, Fang Xiong, Zhaojian Gong, Can Guo, Xiayu Li, Hao Deng, Ke Cao, Ming Zhou, Bo Xiang, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
Language: English
Subfield: Cancer Research
Open Access status: gold
Estimated APC paid: $4,190
Awards: G1474490597, G1696972430, G1979320488, G3075304213, G3192852885, G4248435392, G4744262362, G4748096499, G539742343, G5469440892, G6009453619, G6088520956, G620210533, G7743909951, G8489338662, G856949834, G94838320
OpenAlex ID: W2802832662
FWCI: 12.46
Cites: 190
Cited by: 410
Related to: 10