Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables
Year: 2018
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: The current investigation aimed at studying the sociodemographic, clinical, and neuropsychological variables related to functional outcome in a sample of euthymic patients with bipolar disorder(BD) presenting moderate-severe levels of functional impairment. METHODS: Two-hundred and thirty-nine participants with BD disorders and with Functioning Assessment Short Test(FAST) scores equal or above 18 were administered a clinical and diagnostic interview, and the administration of mood measure scales and a comprehensive neuropsychological battery. Analyses involved preliminary Pearson bivariate correlations to identify sociodemographic and clinical variables associated with the FAST total score. Regarding neuropsychological variables, a principal component analysis (PCA) was performed to group the variables in orthogonal factors. Finally, a hierarchical multiple regression was run. RESULTS: The best fitting model for the variables associated with functioning was a linear combination of gender, age, estimated IQ, Hamilton Depression Rating Scale (HAM-D), number of previous manic episodes, Factor 1 and Factor 2 extracted from the PCA. The model, including all these previous variables, explained up to 29.4% of the observed variance. CONCLUSIONS: Male gender, older age, lower premorbid IQ, subdepressive symptoms, higher number of manic episodes, and lower performance in verbal memory, working memory, verbal fluency, and processing speed were associated with lower functioning in patients with BD.
Source: Acta Psychiatrica Scandinavica
DOI: 10.1111/acps.12894
Authors: J. Sanchez‐Moreno, C. M. Bonnin, A. González‐Pinto, B. L. Amann, B. Solé, V. Balanzá‐Martinez, C. Arango, E. Jiménez, R. Tabarés‐Seisdedos, M. P. Garcia‐Portilla, A. Ibáñez, J. M. Crespo, J. L. Ayuso‐Mateos, A. Martinez‐Aran, C. Torrent, E. Vieta, CIBERSAM Functional Remediation Group
Institutions: Centro de Investigación Biomédica en Red de Salud Mental, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, University of the Basque Country, Universitat Autònoma de Barcelona, Parc de Salut, Hospital del Mar Research Institute, Universitat de València, Hospital Universitari i Politècnic La Fe, Universidad Complutense de Madrid, Hospital General Universitario Gregorio Marañón, Universidad de Oviedo, Servicio de Salud del Principado de Asturias, Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, Bellvitge University Hospital, Institut d'Investigació Biomédica de Bellvitge, Universidad Autónoma de Madrid
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Brain and Behavior Research Foundation, Amgen, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, AstraZeneca, Sanofi, Sunovion, National Alliance for Research on Schizophrenia and Depression, Centres de Recerca de Catalunya, Generalitat de Catalunya, Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya, Eusko Jaurlaritza, Ministerio de Economía y Competitividad, Gedeon Richter, Ministerio de Ciencia e Innovación, Centro de Investigación Biomédica en Red de Salud Mental, Otsuka Pharmaceutical, Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España, Servier, H. Lundbeck A/S, Allergan, Instituto de Salud Carlos III, European Regional Development Fund, Cilag
Awards: Implicación de variantes del gen DDR1 en la integridad de la mielina y en la velocidad de procesamiento cognitivo en pacientes con trastorno bipolar en fase eutímica, G1463422760, G1708496759, G183406716, G2011133403, G2180604724, G2379529563, G2620658983, G2751354829, G3113984991, G3136903196, G3284007754, G3288897321, Eficacia de un un módulo e-neurocognitivo como coadyuvante a la rehabilitación funcional para pacientes con trastorno bipolar, G4223732870, G4704457972, G483405385, G5695398490, G5893827543, G7245015376, G7387235269, G8794265397
OpenAlex ID: W2802881766