Study of the chlorination of guanosine monophosphate by hypochlorous acid using a rotating platinum electrode
Year: 2017
Type: article
Abstract: The in vitro chlorination of the nucleotide Guanosine Monophospate (GMP) by Hypochlorous acid (HOCl) has been herein studied. The in vivo chlorination of nucleobases and nucleotides gives rise to mismatch pairing in genetic coding which in turn results in abnormal protein synthesis and consequently diseases. The reaction studied is found to be rapid and the use of the special kinetic technique - hydrodynamic voltammetry has been adopted. The chlorination results in the formation of the mono-chloro product at position 8 on the substrate nucleotide.
Authors: Willayat Bashir, Dangat Vt
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2802912004